تفاعل #2200

معادلة التفاعل

4-chloro-4'-ethane sulfonylmethylbenzhydrol

thionyl chloride

toluene

→

desired product

المردود 75.0%

4-Chloro-4'-ethane Sulfonylmethylbenzhydryl Chloride

المردود 75.0%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةgradually heated
2. 2
   workup.STIRRINGThe mixture was stirred for 4 hours
3. 3
   درجة الحرارةunder reflux
4. 4
   workup.WAITleft
5. 5
   درجة الحرارةto cool
6. 6
   workup.DISTILLATIONThen, the solvent was distilled off under reduced pressure
7. 7
   أخرىThe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1)

الإجراء التجريبي

4-chloro-4'-ethane sulfonylmethylbenzhydrol (6.0 g), thionyl chloride (5.4 g), toluene (200 ml) and a catalytic amount of N,N-dimethylformamide were mixed and gradually heated with stirring to a refluxing temperature. The mixture was stirred for 4 hours under reflux and then left to cool. Then, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=2:1) to obtain the desired product as a slight yellow viscous substance (4.6 g, nD20 : 1.6044, yield: 75%).

المصدر