تفاعل #219903

معادلة التفاعل

iodomethane

sodium hydride

tetrahydrofuran

3,5-heptandione

→

4-methyl-3,5-heptandione

المردود 94.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGAfter stirred at room temperature for 10 hours
2. 2
   أخرىWhite solid was precipitated
3. 3
   ترشيحThe solid was filtered
4. 4
   غسيلwashed with water
5. 5
   أخرىdried

الإجراء التجريبي

To 0.02 mol sodium hydride was added 100 ml anhydrous tetrahydrofuran, slowly added dropwise 0.02 mol 3,5-heptandione at room temperature. Upon completion, the mixture was stirred for 0.5 hours, then 0.04 mol iodomethane was slowly added dropwise. After stirred at room temperature for 10 hours, 20 ml water was added. White solid was precipitated. The solid was filtered, washed with water, and dried to give 4-methyl-3,5-heptandione as a white solid, and the yield was 94%. m.p. was 91-92° C.

المصدر