تفاعل #219895

معادلة التفاعل

sodium borohydride

sodium hydroxide

water

3,5-heptandione

→

3,5-heptandiol

المردود 90.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىUpon completion, the solvent was removed by reduced pressure distillation
2. 2
   استخلاصthe residue was continuously extracted with 40 ml ethyl acetate for 15 hours
3. 3
   أخرىThe solvent was removed

الإجراء التجريبي

To the mixture of 2.5 g sodium borohydride, 0.05 g sodium hydroxide, and 25 ml water, was added dropwise the solution of 14.2 g 3,5-heptandione in 30 ml methanol at 0-10° C. Upon completion, the solvent was removed by reduced pressure distillation, and the residue was continuously extracted with 40 ml ethyl acetate for 15 hours. The solvent was removed to give 3,5-heptandiol as a white solid with the yield 90%, m.p. 60-65° C. IR spectrum had a strong absorption peak at 3400 cm−1, but had no absorption peak at about 1700 cm−1.

المصدر