تفاعل #2198

معادلة التفاعل

4-bromomethyl-4'-chlorobenzophenone

sodium thiocyanate

ethanol

→

desired product

المردود 42.0%

4-Chloro-4'-thiocyanatomethylbenzophenone

المردود 42.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated
2. 2
   workup.ADDITIONwater was added to the residue
3. 3
   استخلاصThe mixture was extracted with ethyl acetate
4. 4
   غسيلThe ethyl acetate layer was washed with water
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONEthyl acetate was distilled off under reduced pressure
7. 7
   غسيلThe residual solid was washed with a solvent mixture of n-hexane

الإجراء التجريبي

4-bromomethyl-4'-chlorobenzophenone (5.7 g) and sodium thiocyanate (5.5 g) were added to ethanol (50 ml), and the mixture was stirred for one hour at 60° C. The reaction mixture was concentrated, and water was added to the residue. The mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with a solvent mixture of n-hexane:ethyl acetate=10:1 to obtain the desired product (2.2 g, melting point: 129° to 131° C., yield:42%).

المصدر