تفاعل #2197

معادلة التفاعل

4-(3-bromopropyl)sulfonylmethyl-4'-chlorobenzophenone

sodium hydride

N,N-dimethylacetamide

→

desired product

المردود 50.0%

4-Chloro-4'-(1,1-dioxothiolan-2-yl)benzophenone

المردود 50.0%

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture was extracted with ethyl acetate
2. 2
   غسيلThe ethyl acetate layer was washed with water
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONEthyl acetate was distilled off under reduced pressure
5. 5
   أخرىThe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1)

الإجراء التجريبي

4-(3-bromopropyl)sulfonylmethyl-4'-chlorobenzophenone (2.5 g) and 60% sodium hydride (0.3 g) were added to N,N-dimethylacetamide (70 ml), and the mixture was stirred for 16 hours at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the desired product as a slightly yellow viscous substance 1.0 g, yield: 50%).

المصدر