تفاعل #2195473

معادلة التفاعل

phenol

sodium hydride

HCl

→

Dibenzofuran

المذيبات

DMSO

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe aqueous phase is extracted with MTB ether
2. 2
   تجفيفThe organic phase is dried over sodium sulfate
3. 3
   أخرىevaporated
4. 4
   أخرىchromatographed on silica gel

الإجراء التجريبي

The phenol 10 is dissolved in DMSO under nitrogen, a 60% sodium hydride/mineral oil suspension is added, and the mixture is warmed to 120° C. After 5 hours at this temperature, the cooled batch is added to dil. HCl solution. The aqueous phase is extracted with MTB ether. The organic phase is dried over sodium sulfate, evaporated and chromatographed on silica gel.

المصدر