تفاعل #2195

معادلة التفاعل

4-bromomethyl-4'-chlorobenzophenone

methylmercaptan sodium

→

desired product

المردود 83.0%

4-Chloro-4'-methylthiomethylbenzophenone

المردود 83.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux
2. 2
   تركيزThe reaction mixture was concentrated
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   غسيلThe ethyl acetate layer was washed with water
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONEthyl acetate was distilled off under reduced pressure
7. 7
   غسيلThe residual solid was washed with n-hexane

الإجراء التجريبي

4-bromomethyl-4'-chlorobenzophenone (3.1 g) and 15% methylmercaptan-sodium aqueous solution (5.6 g) were added to methanol (150 ml), and the mixture was stirred for 30 minutes under reflux. The reaction mixture was concentrated and extracted with ethyl acetate. The ethyl acetate layer was washed with water and then dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (2.3 g, melting point: 59° to 61° C., yield: 83%).

المصدر