تفاعل #2194125

معادلة التفاعل

sulfuric acid

5-bromo-2-chloro-3-nitrobenzoic acid

methanol

→

5-bromo-2-chloro-3-nitrobenzoic acid methyl ester

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 16 hours
2. 2
   درجة الحرارةsubsequently cooled with an ice bath
3. 3
   أخرىthe resulting precipitate is isolated by filtration
4. 4
   تركيزThe mother liquor is concentrated
5. 5
   workup.ADDITIONwater is added
6. 6
   أخرىthe resulting precipitate is isolated by filtration

الإجراء التجريبي

20 ml of concentrated sulfuric acid are added dropwise to 51.0 g (0.182 mol) of 5-bromo-2-chloro-3-nitrobenzoic acid and 500 ml of methanol. The mixture is then boiled under reflux for 16 hours and subsequently cooled with an ice bath and the resulting precipitate is isolated by filtration. The mother liquor is concentrated, water is added and the resulting precipitate is isolated by filtration.

المصدر