تفاعل #219296

معادلة التفاعل

(E)-tert-butyl 1-(3-tert-butylphenyl)-3-((dimethylamino) methylene)-4-oxocyclohexylcarbamate

hydrazine monohydrate

→

Tert-butyl 5-(3-tert-butylphenyl)-4,5,6,7-tetrahydro-2H-indazol-5-ylcarbamate

المردود 67.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction was concentrated
2. 2
   أخرىpurified
3. 3
   غسيلeluting with DCM/MeOH (95:5)
4. 4
   أخرىto afford 500 mg (67% yield) of an off white foam

الإجراء التجريبي

To a stirred solution of (E)-tert-butyl 1-(3-tert-butylphenyl)-3-((dimethylamino) methylene)-4-oxocyclohexylcarbamate (801 mg, 2.0 mmol) in 6 mL of ethanol was added hydrazine monohydrate (150 μL, 3.0 mmol). The reaction was allowed to stir for 3 h. The reaction was concentrated and purified using a biotage 40S column eluting with DCM/MeOH (95:5) to afford 500 mg (67% yield) of an off white foam. LCMS corresponded to the desired material: retention time (min)=2.45 (method [8]); MS (ESI) 370.0.

المصدر