تفاعل #2191

معادلة التفاعل

N-(4-chloro-4'-trifluoromethylsulfonylmethylbenzhydryl) -N'-methoxycarbonylhydrazine

hydrochloric acid

→

desired product

N-(4-Chloro-4'-trifluoromethylsulfonylmethylbenzhydryl)-N'-methoxycarbonylhydrazine Hydrochloride

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   درجة الحرارةThe mixture was gradually heated to the reflux temperature
3. 3
   workup.STIRRINGstirred for 2 hours
4. 4
   درجة الحرارةunder reflux
5. 5
   workup.WAITit was left
6. 6
   درجة الحرارةto cool
7. 7
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

الإجراء التجريبي

N-(4-chloro-4'-trifluoromethylsulfonylmethylbenzhydryl) -N'-methoxycarbonylhydrazine (1.6 g) was added to methanol (80 ml), and hydrochloric acid (3 ml) was added thereto with stirring at room temperature. The mixture was gradually heated to the reflux temperature and stirred for 2 hours under reflux, and then it was left to cool. The solvent was distilled off under reduced pressure to obtain the desired product as a slightly yellow powder (1.6 g, melting point: 52° to 54° C., yield: 91.5%).

المصدر