تفاعل #2190295

معادلة التفاعل

2,2-Diphenyl-1,3-benzodioxol-5-amine

N-ethyldiisopropyl amine

benzenesulfonyl chloride

→

product

المردود 6.0%

N-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-benzenesulfonamide

المردود 6.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلThe reaction was washed with cold 1N aqueous HCl, with 1N aqueous NaOH and with saturated aqueous sodium chloride solution
2. 2
   تجفيفThe organic layer was dried over sodium sulfate
3. 3
   ترشيحfiltered
4. 4
   أخرىthe solvent was evaporated in vacuo
5. 5
   أخرىThe residue was purified by column chromatography
6. 6
   أخرىThe product was crystallized from hexane

الإجراء التجريبي

2,2-Diphenyl-1,3-benzodioxol-5-amine was dissolved in dichloromethane (5 ml). N-ethyldiisopropyl amine (0.1 ml. 0.6 mmol) and benzenesulfonyl chloride (88 mg, 0.5 mmol) were added. The reaction was stirred for 5 hours at room temperature. The reaction was washed with cold 1N aqueous HCl, with 1N aqueous NaOH and with saturated aqueous sodium chloride solution. The organic layer was dried over sodium sulfate, filtered and the solvent was evaporated in vacuo. The residue was purified by column chromatography using dichloromethane as the eluant. The product was crystallized from hexane to yield the product as white crystals (12 mg, 6%).

المصدر