تفاعل #219022

معادلة التفاعل

4,5-dichloro-2-(2,3-dimethoxyphenoxy)aniline

2,3-dimethoxyphenol

4,5-dichloro-2-fluoro-1-nitrobenzene

4,5-dichloro-2-(2,3-dimethoxyphenoxy)aniline

2-aminothiazole

→

4,5-Dichloro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene

المردود 65.0%

N-[4,5-Dichloro-2-(2,3-dimethoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea

المردود 62.0%

ظروف التفاعل

الإجراء التجريبي

4,5-Dichloro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene (1.12 g, 65%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 4,5-dichloro-2-fluoro-1-nitrobenzene (1.05 g, 5.0 mmol) following the general procedure A. This was reduced to 4,5-dichloro-2-(2,3-dimethoxyphenoxy)aniline (0.68 g, 67%) following general procedure B. N-[4,5-Dichloro-2-(2,3-dimethoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (136 mg, 62%) was prepared from 4,5-dichloro-2-(2,3-dimethoxyphenoxy)aniline (157 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

المصدر