تفاعل #218860

ord-63abf9f8d5a844d6bb748b36310294b4

معادلة التفاعل

Cc1nnc(-c2ccc(C)c(-c3ccc(C(=O)O)cc3)c2)o1
2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid
COc1cccc(CN)c1
3-methoxybenzylamine
COc1cccc(CNC(=O)c2ccc(-c3cc(-c4nnc(C)o4)ccc3C)cc2)c1
N-(3-Methoxybenzyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

N-(3-Methoxybenzyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 3-methoxybenzylamine using method N. NMR; δH [2H6]—DMSO 9.12,(1H, t), 8.00,(2H, d), 7.90,(1H, dd), 7.76,(1H, d), 7.56-7.51,(3H, m), 7.24,(1H, t), 6.90,(2H, m), 6.83,(1H, dd), 4.48,(2H, d), 3.73,(3H, s), 2.56,(3H, s), 2.31,(3H, s). LCMS; retention time 3.34 min, MH+ 414.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07384963B2uspto-grants-2008_06