تفاعل #218765

معادلة التفاعل

sodium bisulfite

sodium acetate

Isovanillin

bromine

→

2-bromoisovanillin

المردود 45.9%

المذيبات

acetic acid

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىThe system was flushed thoroughly with nitrogen
2. 2
   workup.STIRRINGstirred for 10 min
3. 3
   ترشيحThe precipitate was filtered
4. 4
   غسيلwashed with water (100 ml)
5. 5
   أخرىdried

الإجراء التجريبي

Isovanillin (5 gm, 0.033 mol) was dissolved in glacial acetic acid (30 ml). Anhydrous sodium acetate (5.4 gm) was added to the above solution followed by powdered iron (0.15 gm). The system was flushed thoroughly with nitrogen. A solution of bromine (5.79 gm, 0.0362 mol) in glacial acetic acid (10 ml) was added to the above stirred suspension at room temperature over a period of 15 min. The reaction mixture was stirred at room temperature for 45 min. The reaction mixture was poured into aqueous 2% sodium bisulfite (200 ml) and stirred for 10 min. The precipitate was filtered washed with water (100 ml), and dried to obtain 3.5 gm of 2-bromoisovanillin as white powder mp: (200-202° C.).

المصدر