تفاعل #2186210

معادلة التفاعل

3-Piperazin-1-yl-phenol

K2CO3

2-(3-bromo-propoxy)-tetrahydro-pyran

→

desired product

المردود 49.4%

3-{4-[3-(Tetrahydro-pyran-2-yloxy)-propyl]-piperazin-1 -yl}-phenol

المردود 49.4%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled below 5° C
2. 2
   استخلاصextracted with AcOEt after dilution with saline
3. 3
   تجفيفThe organic phase is dried over sodium sulfate
4. 4
   أخرىevaporated
5. 5
   أخرىthe residue column chromatographed (silica gel, AcOEt/EtOH 95:5)

الإجراء التجريبي

712 mg (4 mmol) 3-Piperazin-1-yl-phenol are dissolved in 30 mL DMF under argon and cooled below 5° C. After addition of 1.38 g (2.5 eq.) K2CO3, 166 mg (0.25 eq.) KI and 888 mg (1 eq.) 2-(3-bromo-propoxy)-tetrahydro-pyran, the suspension is stirred at room temperature for 20 hours, then extracted with AcOEt after dilution with saline. The organic phase is dried over sodium sulfate, evaporated and the residue column chromatographed (silica gel, AcOEt/EtOH 95:5) to yield 630 mg (48%) desired product as a light yellowish resin.

المصدر