تفاعل #2186196

معادلة التفاعل

1-(2-Fluoro-ethyl)-7-hydroxy-1,2,3,4-tetrahydro-quinoline-6-carbaldehyde

(6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester

piperidine

→

desired product

المردود 67.4%

3-(6-Chloro-imidazo[1,2-a]pyridin-2-yl)-8-(2-fluoro-ethyl)-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one

المردود 67.4%

المذيبات

benzene

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 18 h
2. 2
   أخرىto reach room temperature
3. 3
   ترشيحthe precipitate filtered
4. 4
   غسيلwashed with acetonitrile
5. 5
   أخرىdried under high vacuum

الإجراء التجريبي

200 mg (0.896 mmol) 1-(2-Fluoro-ethyl)-7-hydroxy-1,2,3,4-tetrahydro-quinoline-6-carbaldehyde and 201 mg (1 eq.) (6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester in 6 mL benzene and 3 mL acetonitrile are treated with 0.177 mL (2 eq.) piperidine and refluxed for 18 h. The reaction mixture is allowed to reach room temperature and the precipitate filtered, washed with acetonitrile and dried under high vacuum to yield 240 mg (67%) of desired product as a yellow powder.

المصدر