تفاعل #2186191

معادلة التفاعل

4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde

benzothiazol-2-yl-acetic acid methyl ester

piperidine

→

desired product

المردود 55.0%

3-Benzothiazol-2-yl-7-[4-(2-fluoro-ethyl)-piperazin-1-yl]-chromen-2-one

المردود 55.0%

المذيبات

benzene

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىto reach room temperature
2. 2
   ترشيحthe precipitate filtered off
3. 3
   غسيلwashed with diethylether
4. 4
   أخرىdried under high vacuum

الإجراء التجريبي

200 mg (0.793 mmol) 4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde and 164 mg (1 eq.) benzothiazol-2-yl-acetic acid methyl ester are heated to reflux for 3 h in 5 mL benzene and 2.5 mL acetonitrile, in the presence of 0.157 mL (2 eq.) piperidine. The reaction mixture is allowed to reach room temperature and the precipitate filtered off, washed with diethylether and dried under high vacuum to yield 90 mg (55%) of desired product as a yellow powder (melting point: 246° C.).

المصدر