تفاعل #2186167

معادلة التفاعل

acetone

sulfuric acid

L-ascorbic acid

→

5,6-O-isopropylidene-L-ascorbic acid

المردود 115.4%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was then reacted at the temperature of the previous step for 17 hours
2. 2
   ترشيحfiltered
3. 3
   غسيلwashed with cold acetone

الإجراء التجريبي

With nitrogen substitution, 557.8 grams (9.6 moles) of acetone was cooled to −5 degrees C., 54.3 grams (0.2 moles) of 28% fuming sulfuric acid was dripped, and 176.1 grams (1.0 mole) of L-ascorbic acid was added. The mixture was then reacted at the temperature of the previous step for 17 hours, filtered and washed with cold acetone to obtain 249.5 grams of 5,6-O-isopropylidene-L-ascorbic acid (86.7% in purity) in the form of a wet cake.

المصدر