تفاعل #218470

معادلة التفاعل

malononitrile

acetoin

diethylamine

→

2-amino-4,5-dimethyl-3-furonitrile

المردود 75.0%

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe precipitated crystals are collected by filtration

الإجراء التجريبي

To a solution of malononitrile (28.2 g) in methanol (30 mL) is added a suspension of acetoin (25 g) in methanol (30 mL) and thereto is added dropwise diethylamine (11 mL) under ice-cooling (internal temp.: 10° C.). The mixture is stirred at room temperature for 3 hours. The reaction mixture is poured into ice water (300 mL) and the precipitated crystals are collected by filtration to give 2-amino-4,5-dimethyl-3-furonitrile (28.91 g, yield; 75%) as colorless crystals.

المصدر