تفاعل #218347

معادلة التفاعل

4-ethoxy-2-hydroxy-5-methyl-benzaldehyde

sodium acetate

acetic acid

nitroethane

→

2-hydroxy-5-hydroxymethoxy-benzonitrile

المردود 61.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe black reaction mixture
2. 2
   استخلاصextracted 5 times with diethyl ether (100 mL)
3. 3
   غسيلwashed 3 times with sat. sodium bicarbonate solution (25 mL), one time with brine
4. 4
   تجفيفdried with sodium sulfate
5. 5
   تركيزan finally concentrated in vacuo
6. 6
   أخرىto give a black colored oil
7. 7
   أخرىPurification by MPLC chromatography (Biotage)

الإجراء التجريبي

A mixture of 4-ethoxy-2-hydroxy-5-methyl-benzaldehyde (2.4 g, 14.6 mmol), sodium acetate (2.40 g, 29.25 mmol, 2.0 eq), acetic acid (3.4 g, 57.1 mmol, 3.9 eq), and nitroethane (2.2 g, 29.25 mmol, 2.0 eq) was heated in a sealed tube at 115° C. for 18 h. The black reaction mixture was poured into 40 g of ice and extracted 5 times with diethyl ether (100 mL). The organic layers were combined, washed 3 times with sat. sodium bicarbonate solution (25 mL), one time with brine, dried with sodium sulfate an finally concentrated in vacuo to give a black colored oil. Purification by MPLC chromatography (Biotage) using a hexane-ethyl acetate gradient gave 1.45 g (61%) of 2-hydroxy-5-hydroxymethoxy-benzonitrile as an orange solid. 1H-NMR (DMSO-d6) δ 10.69 (s, 1H), 7.04 (s, 1H), 6.51 (1, 2H), 6.01 (s, 2 H); TLC Rf=0.73, 50% ethyl acetate-hexanes.

المصدر