تفاعل #2180768

معادلة التفاعل

trifluoroacetic acid

tert-butyl({1-[4-(trifluoromethyl)phenyl]piperidin-4-yl}methyl)carbamate

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title compound

المردود 123.5%

1-{1-[4-(Trifluoromethyl)phenyl]piperidin-4-yl}methanamine

المردود 123.5%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   تركيزThe sample was concentrated
2. 2
   استخلاصThe mixture was extracted
3. 3
   تجفيفthe organic layer was dried over sodium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated in vacuo

الإجراء التجريبي

A mixture of trifluoroacetic acid (10 ml) and dichloromethane (10 ml) was added to tert-butyl({1-[4-(trifluoromethyl)phenyl]piperidin-4-yl}methyl)carbamate (1.36 g). This mixture was stirred at room temperature for 3 h. The sample was concentrated and taken up in dichloromethane (20 ml) and saturated aqueous sodium bicarbonate. The mixture was extracted and the organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to provide the title compound (1.21 g, 86%). Mass spectrum (ESI) 242.1 (M+1).

المصدر