تفاعل #217546

معادلة التفاعل

4-(1H-Indol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

→

4-(1H-Indol-4-yl)-piperidine-1-carboxylic acid tert-butyl ester

المردود 96.6%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered through a plug of celite
2. 2
   أخرىcapped with a glass
3. 3
   ترشيحfilter
4. 4
   تركيزThe filtrate was concentrated

الإجراء التجريبي

A mixture of 4-(1H-Indol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 4-6 (670 mg, 2.24 mmol) and 10% Pd/C (70 mg) in ethanol (75 mL) was placed under H2 atmosphere on the parr shaker at 50 psi, and was shaken overnight. The reaction mixture was filtered through a plug of celite capped with a glass filter. The filtrate was concentrated to afford (650 mg, 96%) of 4-(1H-Indol-4-yl)-piperidine-1-carboxylic acid tert-butyl ester 4-7. Step 6

المصدر