تفاعل #2175458

معادلة التفاعل

9-formyl-2,7-fluorenedicarboxylic acid

sodium borohydride

→

9-hydroxymethyl-2,7-fluorenedicarboxylic acid

المذيبات

water

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىto react for two hours
2. 2
   أخرىThe reaction was quenched with the careful addition of 1 M HCl until acidic
3. 3
   استخلاصThe product was extracted with ethyl acetate
4. 4
   تجفيفdried over sodium sulfate
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated to dryness

الإجراء التجريبي

A small sample of 9-formyl-2,7-fluorenedicarboxylic acid (5-10 mg) was dissolved in water with a small amount of THF. An excess amount of sodium borohydride was added and allowed to react for two hours. The reaction was quenched with the careful addition of 1 M HCl until acidic. The product was extracted with ethyl acetate, dried over sodium sulfate, filtered and evaporated to dryness. 1H-NMR (CD3OD): δ (ppm) 8.4 (s, 2H, Ar); 8.2 (m, 2H, Ar); 8.0 (m, 2H, Ar); 4.2 (t, 1H, CH); 4.0 (d, 2H, CH2).

المصدر