تفاعل #2174

معادلة التفاعل

3-cyano-5-(4-chlorophenyl)-2-pyridinone

→

5-(4-chlorophenyl)-2-pyridinone

المردود 75.6%

المذيبات

H3PO4

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 16 hours
3. 3
   ترشيحfiltered

الإجراء التجريبي

A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.

المصدر