تفاعل #217177
ord-de5992a38fdb48f288f21e3b7c34d3a1
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1تركيزconcentrated under reduced pressure
- 2أخرىThe residue was purified
- 3تجفيفby dry column flash chromatography (Merck, Kieselgel 60) with chloroform/methanol=10/1
- 4غسيلfor elution
الإجراء التجريبي
To a solution of Leu-DTrp-βAla-OEt-TFA (40.6 mg) obtained in Example 51-(1) in chloroform (2 ml) were added TEA (20 μl) and phenyl isocyanate (15 μl) at room temperature under nitrogen. The reaction mixture was stirred for 1 h, and concentrated under reduced pressure. The residue was purified by dry column flash chromatography (Merck, Kieselgel 60) with chloroform/methanol=10/1 for elution to give the product (39.6 mg).