تفاعل #217155

معادلة التفاعل

1-dimethylcarbamoyl-3-t-butyl-5-carboethoxymethylthio-1H-1,2,4-triazole

compound

1-dimethylcarbamoyl-3-t-butyl-5-carboethoxymethylthio-1,2,4-1H-triazole

HCl

→

1-dimethylcarbamoyl-3t-butyl-5-carboxymethylthio-1H-1,2,4-triazole

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىwas partitioned between ether and water
2. 2
   استخلاصthe ether layer was extracted with dilute NaOH
3. 3
   استخلاصextracted with fresh ether
4. 4
   تجفيفThe resulting ether layer was dried over magnesium sulfate
5. 5
   ترشيحfiltered
6. 6
   أخرىevaporated under vacuum

الإجراء التجريبي

To 1.2 g of 1-dimethylcarbamoyl-3-t-butyl-5-carboethoxymethylthio-1H-1,2,4-triazole (the compound of Example 2) in 20 ml of THF was added 4 ml of 12M HCl. After stirring for 48 h at 200° C. the reaction mixture was partitioned between ether and water, the ether layer was extracted with dilute NaOH and the resulting aqueous layer was acidified and extracted with fresh ether. The resulting ether layer was dried over magnesium sulfate, filtered and evaporated under vacuum to yield 1-dimethylcarbamoyl-3t-butyl-5-carboxymethylthio-1H-1,2,4-triazole as an oil.

المصدر