تفاعل #216744

معادلة التفاعل

1-cyano-2-methoxybenzene

tributyltin azide

→

5-(2-methoxyphenyl)-2H-tetrazole

المردود 98.1%

المذيبات

diethyl ether

xylene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 5 hours
3. 3
   درجة الحرارةThe reaction mixture then was cooled
4. 4
   أخرىAnhydrous hydrochloric acid was bubbled into the mixture
5. 5
   أخرىa white precipitate formed
6. 6
   ترشيحThe precipitate was collected by suction filtration
7. 7
   غسيلwashed repeatedly with diethyl ether
8. 8
   أخرىDrying

الإجراء التجريبي

A mixture of 1-cyano-2-methoxybenzene (1.02 g, 7.7 mmol) and tributyltin azide (3.4 g, 10.0 mmol) in 3.0 mL of xylene was heated under reflux for 5 hours. The reaction mixture then was cooled and diluted with diethyl ether. Anhydrous hydrochloric acid was bubbled into the mixture and a white precipitate formed. The precipitate was collected by suction filtration and washed repeatedly with diethyl ether. Drying gave 5-(2-methoxyphenyl)-2H-tetrazole (1.33 g, 7.55 mmol).

المصدر