تفاعل #2166

معادلة التفاعل

6-(4-chlorophenyl)-4,5-dihydropyridazinone

acetic acid

bromine

→

6-(4-chlorophenyl)pyridazinone

المردود 93.1%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated at 60°-70° C. for 3 h
2. 2
   درجة الحرارةThe resulting mixture was cooled
3. 3
   ترشيحThe resulting white solid was filtered
4. 4
   أخرىdried

الإجراء التجريبي

To a solution of 6-(4-chlorophenyl)-4,5-dihydropyridazinone (11.75 g) and glacial acetic acid (100 ml) was added dropwise 3 ml of bromine and the mixture was heated at 60°-70° C. for 3 h. The resulting mixture was cooled and slowly poured into 400 ml of cold water. The resulting white solid was filtered and dried to yield 10.83 g (89%) of 6-(4-chlorophenyl)pyridazinone.

المصدر