تفاعل #216279

معادلة التفاعل

5-methyluridine

methanesulfonyl chloride

→

2',3',5'-Tris(methanesulfonyl)-5-methyluridine

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGwith stirring
2. 2
   أخرىTrimethanesulfonyl-5-methyluridine (2) precipitated
3. 3
   workup.STIRRINGthe mixture was stirred for 5 min
4. 4
   ترشيحThe solid product was collected by filtration
5. 5
   غسيلwashed with water (3×200 mL)
6. 6
   أخرىdried
7. 7
   أخرىYield

الإجراء التجريبي

To a stirred mixture of 5-methyluridine (12.8 g, 50 mmol) in pyridine (75 mL) at 0° C. was added methanesulfonyl chloride (17.4 mL, 225 mmol). The reaction mixture was stirred at 0° C. for five hours then poured into ice-water (500 mL) with stirring. Trimethanesulfonyl-5-methyluridine (2) precipitated and the mixture was stirred for 5 min. The solid product was collected by filtration and washed with water (3×200 mL) and dried. Yield, 21.6 g, 89%.

المصدر