تفاعل #216260

معادلة التفاعل

4-piperidone hydrochloride hydrate

4-chlorobenzoyl chloride

potassium carbonate

→

title compound

المردود 74.6%

N-(4-Chlorobenzoyl)-4-piperidone

المردود 74.6%

المذيبات

tetrahydrofuran

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added successively
2. 2
   أخرىThe organic phase is then separated off
3. 3
   استخلاصthe aqueous phase is extracted twice more with ethyl acetate
4. 4
   أخرىdried
5. 5
   أخرىevaporated down
6. 6
   workup.DISSOLUTIONThe residue is dissolved in ethyl acetate
7. 7
   workup.ADDITIONthe solution is treated with petroleum ether

الإجراء التجريبي

87.5 g of 4-chlorobenzoyl chloride and a solution of 276 g of potassium carbonate in 552 ml of water cooled to 5° C. are added successively with stirring to a suspension of 80.6 g of powdered 4-piperidone hydrochloride hydrate in 1 l of tetrahydrofuran. The mixture is stirred at ambient temperature for a further 45 minutes. The organic phase is then separated off, the aqueous phase is extracted twice more with ethyl acetate, and the organic phases are combined, dried and evaporated down. The residue is dissolved in ethyl acetate and the solution is treated with petroleum ether. 88.6 g of the title compound of melting point 61°-63° C. are obtained.

المصدر