تفاعل #216159

معادلة التفاعل

tin (II) chloride

product

(R)-4-(4-Aminobenzyl]-1,3-oxazolidin-2-one hydrochloride

HCl

sodium nitrite

HCl

→

desired product

المردود 100.2%

(R)-4-(4-Hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride

المردود 100.2%

المذيبات

water

water

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRING' stirring at room temperature
2. 2
   أخرىThe solution was evaporated in vacuo
3. 3
   أخرىthe residue triturated with ether

الإجراء التجريبي

The product from step (b) (10.3 g) was suspended in water (53 ml) and c.HCl (106 ml) added dropwise. The resulting mixture was cooled to -5° C. and a solution of sodium nitrite (3.2 g) in water (30 ml) added dropwise to the stirred mixture over 15 minutes followed by 30 minutes' stirring at -5° to 0° C. The solution was then added at 0° C. over 15 minutes to a stirred solution of tin (II) chloride (51 g) in c.HCl (91 ml), followed by 3 hours' stirring at room temperature. The solution was evaporated in vacuo and the residue triturated with ether to give the desired product as a pale yellow solid (11 g).

المصدر