تفاعل #2161255

معادلة التفاعل

4-(trifluoromethoxy)phenyl isocyanate

ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىsynthesis in analogy to Example 4A step 3
2. 2
   ترشيحThe reaction mixture is filtered
3. 3
   تركيزthe filtrate is concentrated in vacuo
4. 4
   أخرىpurified chromatographically

الإجراء التجريبي

Under argon, 1.46 g (7.21 mmol) of 4-(trifluoromethoxy)phenyl isocyanate are added to 1.22 g (3.61 mmol) of ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (synthesis in analogy to Example 4A step 3, or also according to Tetrahedron Lett. 2003, 44, 1607 and the literature cited therein) in 50 ml of THF, and the mixture is stirred at room temperature overnight. The reaction mixture is filtered and the filtrate is concentrated in vacuo and purified chromatographically.

المصدر