تفاعل #2161251

معادلة التفاعل

ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate

hydrogen

→

Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst is filtered off
2. 2
   تركيزthe filtrate is concentrated in vacuo
3. 3
   أخرىThe concentration residue is directly used further for the next reaction

الإجراء التجريبي

3.89 g (16.26 mmol) of ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate are dissolved in 50 ml of THF, and a spatula tip of Raney nickel is added. In a hydrogenation apparatus, the reaction mixture is hydrogenated with hydrogen at room temperature. The catalyst is filtered off and the filtrate is concentrated in vacuo. The concentration residue is directly used further for the next reaction.

المصدر