تفاعل #2161248

معادلة التفاعل

ammonium formate

ethyl 1-benzyl-1H-imidazole-2-carboxylate

ammonium formate

→

Ethyl imidazole-2-carboxylate

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture is heated
2. 2
   درجة الحرارةunder reflux for about 6 h
3. 3
   درجة الحرارةAfter cooling
4. 4
   ترشيحthe catalyst is filtered off
5. 5
   تركيزthe filtrate is concentrated in vacuo
6. 6
   أخرىThe product that crystallizes out during this operation
7. 7
   أخرىis triturated with 80 ml of ice-water
8. 8
   ترشيحcollected by suction filtration

الإجراء التجريبي

34.7 g (150.9 mmol) of ethyl 1-benzyl-1H-imidazole-2-carboxylate are dissolved in 1005 ml of ethanol, and 34 g of ammonium formate are added. The reaction mixture is heated under reflux for about 6 h. A total of 8 g of 10% palladium-on-carbon and 18 g of ammonium formate are thereby added in small portions. After cooling, the catalyst is filtered off and the filtrate is concentrated in vacuo. The product that crystallizes out during this operation is triturated with 80 ml of ice-water and collected by suction filtration.

المصدر