تفاعل #215851
ord-82bddaaa76b1434a962a544ffbe9ebaa
معادلة التفاعل
المتفاعلات
الكواشف
المذيبات
ظروف التفاعل
المعالجة
- 1أخرىprepared
- 2درجة الحرارةThe resulting yellow solution was refluxed under a N2 atmosphere for 16 hours
- 3استخلاصThe reaction mixture was extracted with sodium hydroxide (1M, 2×200 mL)
- 4استخلاصextracted with ethyl acetate (3×200 mL)
- 5تجفيفdried (Na2SO4)
- 6أخرىevaporated
الإجراء التجريبي
To a solution of 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide (1) (1.5 g, 5 mmol), prepared as described above in Example 1, and methyl 4-(4-pyridyl)butanoate (48) (2.4 g, 13 mmol), prepared as described above in Example 48, in toluene (250 mL) was added dimethylaluminumchloride (20.0 mmol). The resulting yellow solution was refluxed under a N2 atmosphere for 16 hours. The reaction mixture was allowed to cool to room temperature, followed by the addition of methanol (7 mL). The reaction mixture was extracted with sodium hydroxide (1M, 2×200 mL), and the aqueous extracts were combined and extracted with ethyl acetate (3×200 mL). The organic solutions were combined, dried (Na2SO4) and evaporated to yield 1.8 g of crude product as a thick oil.