تفاعل #215817

معادلة التفاعل

cyproheptadine

hydrogen

→

4-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine

المردود 94.2%

المذيبات

acetic acid

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحFiltered
2. 2
   أخرىevaporated filtrate
3. 3
   أخرىto give a solid
4. 4
   أخرىRecrystallized crude product from ether-pet ether

الإجراء التجريبي

Dissolved cyproheptadine (22.2 g, 0.077 mol) in 150 mL of glacial acetic acid and 20 mL of ethanol. Added platinum oxide catalyst (1.0 g), and hydrogenated on Paar shaker at 57 psi of hydrogen pressure for 5 hours. Filtered, and evaporated filtrate to give a solid. Recrystallized crude product from ether-pet ether to give 21.0 g (94% yield) of 4-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine as a white solid.

المصدر