تفاعل #215813

معادلة التفاعل

ethyl 7-ethoxy-4-(4-methoxyanilino)-1,8-naphthyridine-3-carboxylate hydrochloride

→

ethyl 4-[4-methoxyanilino]-7-oxo-7,8-dihydro-1,8-naphthyridine-3-carboxylate

المذيبات

sodium hydroxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated on a steam bath for 4 hours
2. 2
   درجة الحرارةThe mixture was cooled
3. 3
   ترشيحfiltered
4. 4
   workup.DISSOLUTIONThe residue was dissolved in IMS
5. 5
   أخرىhydrogen chloride gas bubbled through this solution
6. 6
   workup.ADDITIONEther was added
7. 7
   أخرىcrystallisation
8. 8
   ترشيحthe mixture was filtered

الإجراء التجريبي

A mixture of ethyl 7-ethoxy-4-(4-methoxyanilino)-1,8-naphthyridine-3-carboxylate hydrochloride (2.6 g) and 5M sodium hydroxide solution (60 ml) was heated on a steam bath for 4 hours. The mixture was cooled and filtered. The residue was dissolved in IMS and hydrogen chloride gas bubbled through this solution. Ether was added to induce crystallisation and the mixture was filtered to give ethyl 4-[4-methoxyanilino]-7-oxo-7,8-dihydro-1,8-naphthyridine-3-carboxylate 0.3 hydrochloride hemihydrate, m.p. 243°-246° C.

المصدر