تفاعل #215676

معادلة التفاعل

4-(benzyloxy)phenol

potassium methoxide

4-(trifluoromethoxy)-2-nitro-1-chlorobenzene

→

4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONTo a mixture of 10.01 g
2. 2
   درجة الحرارةThe mixture is heated
3. 3
   أخرىthe reaction
4. 4
   أخرىMost of the solvent is removed at reduced pressure
5. 5
   workup.ADDITIONthe residue treated with methylene chloride and water
6. 6
   غسيلThe methylene chloride solution is washed with saturated brine
7. 7
   أخرىdried
8. 8
   أخرىthe solvent removed

الإجراء التجريبي

To a mixture of 10.01 g. of 4-(benzyloxy)phenol and 3.51 g. (0.05 mole) of potassium methoxide in 75 ml. of DMF is added 12.08 g. (0.05 mole) of 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene. The mixture is heated to complete the reaction. Most of the solvent is removed at reduced pressure and the residue treated with methylene chloride and water. The methylene chloride solution is washed with saturated brine, dried, and the solvent removed, leaving 4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether.

المصدر