تفاعل #2155663

معادلة التفاعل

sodium hydroxide

methyl[1-(6-chloropyridazin-3-yl)-5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazol-4-yl]acetate

→

Methyl-[1-(6-chloropyridazin-3-yl)-3-methyl-5-phenyl-1H-pyrazol-4-yl]acetate

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe methanol was removed under reduced pressure
2. 2
   workup.ADDITIONthe residue was poured into a mixture of 10 ml of water and 15 ml of dichloromethane
3. 3
   استخلاصThe aqueous phase was extracted with 15 ml of dichloromethane
4. 4
   استخلاصextracted three times with in each case 15 ml of dichloromethane
5. 5
   أخرىDrying of the combined organic phases and removal of the solvent under reduced pressure
6. 6
   أخرىgave 0.207 g (99% of theory) of a brown wax-like solid, melting point 55° C.

الإجراء التجريبي

0.111 g (2.772 mmol) of 2-molar aqueous sodium hydroxide solution was added to 0.200 g (0.554 mmol) of methyl[1-(6-chloropyridazin-3-yl)-5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazol-4-yl]acetate in 8 ml of methanol, and the mixture was stirred at 20° C. for 1 h. The methanol was removed under reduced pressure and the residue was poured into a mixture of 10 ml of water and 15 ml of dichloromethane. The aqueous phase was extracted with 15 ml of dichloromethane, acidified with concentrated hydrochloric acid (pH=3) and extracted three times with in each case 15 ml of dichloromethane. Drying of the combined organic phases and removal of the solvent under reduced pressure gave 0.207 g (99% of theory) of a brown wax-like solid, melting point 55° C.

المصدر