تفاعل #2155662

معادلة التفاعل

3-chloro-6-hydrazinylpyridazine

methyl 4-oxo-3-(phenylcarbonyl)pentanoate

→

Methyl[1-(6-chloropyridazin-3-yl)-5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazol-4-yl]acetate

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 8 h
2. 2
   أخرىThe solvent was removed under reduced pressure which
3. 3
   أخرىgave

الإجراء التجريبي

0.296 g (2.049 mmol) of 3-chloro-6-hydrazinylpyridazine in 5.00 ml of ethanol was added to 0.400 g (1.708 mmol) of methyl 4-oxo-3-(phenylcarbonyl)pentanoate, and the mixture was stirred at reflux for 8 h. The solvent was removed under reduced pressure which gave, after chromatography of the residue, 0.300 g (48% of theory) of a viscous yellow oil.

المصدر