تفاعل #2154888

معادلة التفاعل

potassium carbonate

tert-butyl 3-(3-trimethylsilylpropynoyl)pyrrolo-[3,2-c]pyridine-1-carboxylate

phenylguanidine carbonate

water

→

phenyl-[4-(1H-pyrrolo[3,2-c]pyridin-3-yl)pyrimidin-2-yl]amine

phenyl[4-(1H-pyrrolo[3,2-c]pyridin-3-yl)pyrimidin-2-yl]-amine

المذيبات

ethylene glycol monomethyl ether

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture is heated at the boil for 68 hours
2. 2
   درجة الحرارةAfter cooling
3. 3
   أخرىThe precipitate formed
4. 4
   ترشيحis filtered off with suction
5. 5
   غسيلwashed with water
6. 6
   أخرىdried in vacuo

الإجراء التجريبي

1.2 104 mg (0.75 mmol) of potassium carbonate are added to a solution of 103 mg (0.30 mmol of tert-butyl 3-(3-trimethylsilylpropynoyl)pyrrolo-[3,2-c]pyridine-1-carboxylate and 148 mg (0.75 mmol) of phenylguanidine carbonate in 1.5 ml of ethylene glycol monomethyl ether, and the mixture is heated at the boil for 68 hours. After cooling, 10 ml of water are added, and the mixture is stirred at 40° C. for 1 h. The precipitate formed is filtered off with suction, washed with water and dried in vacuo, giving phenyl-[4-(1H-pyrrolo[3,2-c]pyridin-3-yl)pyrimidin-2-yl]amine (“A1”) as pale-brown solid; ESI 287;

المصدر