تفاعل #215406

معادلة التفاعل

sodium hydroxide

4-phenylthiobenzyl cyanide

butyl chloride

sodium hydroxide

→

pure product

المردود 65.1%

2-(4-Phenylthiophenyl)hexanenitrile

المردود 65.1%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture is heated at 85° for 1/2 hour
2. 2
   درجة الحرارةHeating
3. 3
   استخلاصextracted with ether
4. 4
   غسيلThe combined ether extracts are washed with water, saturated sodium chloride solution
5. 5
   تجفيفdried over MgSO4
6. 6
   أخرىSolvent is evaporated
7. 7
   أخرىto give 47 g of a crude product
8. 8
   workup.DISTILLATIONVacuum distillation (173°-180°/0.05 mm)

الإجراء التجريبي

To a mixture of 41 g (0.18 mole) of 4-phenylthiobenzyl cyanide, 18 g (0.19 mole) of butyl chloride and 2 g of tetraethylammonium bromide is added 16 g (0.2 mole) of 50% sodium hydroxide solution dropwise at room temperature with stirring. The reaction mixture is heated at 85° for 1/2 hour and then an additional 16 g (0.2 mole) of 50% sodium hydroxide solution are added. Heating is continued for another 1/2 hour. The reaction mixture is poured into water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over MgSO4. Solvent is evaporated to give 47 g of a crude product. Vacuum distillation (173°-180°/0.05 mm) gives 33 g of pure product.

المصدر