تفاعل #215285

معادلة التفاعل

3-benzoyloxy-6,7-dimethoxy-1,2,3,4-tetrahydrocarbazole

sodium hydride

ethyl bromoacetate

→

3-benzoyloxy-6,7-dimethoxy-9-carbethoxymethyl-1,2,3,4-tetrahydrocarbazole

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe 3-benzoyloxy-6,7-dimethoxy-9-carbethoxymethyl-1,2,3,4-tetrahydrocarbazole was prepared
2. 2
   ترشيحThe crude product in ethyl acetate was filtered through alumina
3. 3
   أخرىthe filtrate was evaporated to dryness under reduced pressure
4. 4
   أخرىthe residue was recrystallized from ethyl acetate

الإجراء التجريبي

The 3-benzoyloxy-6,7-dimethoxy-9-carbethoxymethyl-1,2,3,4-tetrahydrocarbazole was prepared by following an alkylation procedure similar to that described in Example 11 but using 17.6 g. of 3-benzoyloxy-6,7-dimethoxy-1,2,3,4-tetrahydrocarbazole (see Example 4) and 2.14 g. of sodium hydride (56% in mineral oil) in 200 ml. of dimethylformamide, and 8.4 g. of ethyl bromoacetate. The crude product in ethyl acetate was filtered through alumina, the filtrate was evaporated to dryness under reduced pressure and the residue was recrystallized from ethyl acetate to give 3-benzoyloxy-6,7-dimethoxy-9-carbethoxymethyl-1,2,3,4-tetrahydrocarbazole, m.p. 125°-127° C.

المصدر