تفاعل #215241

معادلة التفاعل

sodium hydride

cyclohexanol

hydrogen

2-nitro-5-chloroaniline

carbomethoxycyanamide

→

5-cyclohexyloxy-2-carbomethoxyaminobenzimidazole

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONis added portionwise
2. 2
   درجة الحرارةThe mixture is warmed at 75°-80° C. for 1 hour
3. 3
   workup.ADDITIONthen poured onto 6 volumes of ice slurry
4. 4
   أخرىThe separated product is recrystallized from water
5. 5
   أخرىto give red crystals of the nitroaminobiphenylether

الإجراء التجريبي

A mixture of cyclohexanol (0.03 mol) in 75 ml. of dry dimethylformamide under nitrogen is agitated while 55% sodium hydride (0.03 mol) in oil is added portionwise. When evolution of hydrogen ceases 2-nitro-5-chloroaniline (0.025 mol) is added with stirring. The mixture is warmed at 75°-80° C. for 1 hour then poured onto 6 volumes of ice slurry. The separated product is recrystallized from water to give red crystals of the nitroaminobiphenylether. After hydrogenation and reaction with carbomethoxycyanamide as described above the product, 5-cyclohexyloxy-2-carbomethoxyaminobenzimidazole is obtained.

المصدر