تفاعل #214884

معادلة التفاعل

pyrazine carboxylic acid hydrazide

Sodium

pyridine-4-carbonitrile

→

3-pyrazinyl-5-(4-pyridyl)-1,2,4-triazole

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONis added
2. 2
   درجة الحرارةthe resulting solution is heated
3. 3
   درجة الحرارةat reflux for 30 minutes
4. 4
   درجة الحرارةAfter cooling
5. 5
   ترشيحthe intermediate acylamidrazone is collected by filtration
6. 6
   درجة الحرارةafter which the reaction is cooled to room temperature
7. 7
   أخرىUpon recrystallization from acetonitrile-water

الإجراء التجريبي

Sodium (0.4 grams) is added to pyridine-4-carbonitrile (8.3 grams, 0.08 mole) in methanol, and the solution is allowed to stand 30 minutes at room temperature. A suspension of pyrazine carboxylic acid hydrazide (9.6 grams, 0.07 mole) in methanol (160 ml.) is added, and the resulting solution is heated at reflux for 30 minutes. After cooling, the intermediate acylamidrazone is collected by filtration. The acyclic intermediate is then heated at 260° C. for 15 minutes, after which the reaction is cooled to room temperature. Upon recrystallization from acetonitrile-water, 3-pyrazinyl-5-(4-pyridyl)-1,2,4-triazole is obtained, m.p. 251°-252.5° C.

المصدر