تفاعل #214770

معادلة التفاعل

1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile

p-aminophenol

→

1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile

المذيبات

xylene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 2 hours
2. 2
   ترشيحfiltered hot
3. 3
   درجة الحرارةThe filtrate is chilled
4. 4
   أخرىthe crystals formed
5. 5
   أخرىcollected
6. 6
   أخرىrecrystallized from methanol

الإجراء التجريبي

The mixture of 5.7 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile, 3,6 g of p-aminophenol and 300 ml of xylene is refluxed for 2 hours and filtered hot. The filtrate is chilled, the crystals formed collected and recrystallized from methanol, to yield the 1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile melting at 182°-184°.

المصدر