تفاعل #2146712

معادلة التفاعل

19

5-tert-Butoxycarbonylamino-5-{2-[4-(5-hydroxyl-1-pentyl)phenyl]ethyl}-2,2-dimethyl-1,3-dioxane

N,N-diisopropylethylamine

lithium iodide

sodium azide

Methanesulfonyl chloride

→

20

المردود 67.0%

5-tert-Butoxycarbonylamino-5-{2-[4-(5-azido-1-pentyl)phenyl]ethyl}-2,2-dimethyl-1,3-dioxane

المردود 67.0%

المذيبات

Water

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىat room temperature
2. 2
   أخرىovernight
3. 3
   غسيلThe mixture was washed with saturated aqueous NaHCO3 solution (2×10 mL), water (2×10 mL), and brine (2×10 mL)
4. 4
   تجفيفdried (Na2SO4)
5. 5
   أخرىAfter the solvent was removed
6. 6
   workup.DISSOLUTIONthe residue was dissolved in dry DMF (5 mL)
7. 7
   workup.STIRRINGThe reaction mixture was stirred at 80° C. for 18 h
8. 8
   درجة الحرارةwas cooled to room temperature
9. 9
   استخلاصthe suspension was extracted with CH2Cl2 (3×20 mL)
10. 10
    غسيلThe combined organic layer was washed with water (3×30 mL) and brine (2×20 mL)
11. 11
    تجفيفdried (Na2SO4)
12. 12
    تركيزconcentrated under vacuum
13. 13
    أخرىThe residue was purified by chromatography (hexanes/EtOAc 4:1)

الإجراء التجريبي

A solution of 19 (168 mg, 0.40 mmol) and N,N-diisopropylethylamine (155 mg, 1.2 mmol) in CH2Cl2 (10 mL) was cooled to 0° C. Methanesulfonyl chloride (66 mg, 0.60 mmol) was added, and the mixture was stirred at 0° C. for 2 h and then at room temperature overnight. The mixture was washed with saturated aqueous NaHCO3 solution (2×10 mL), water (2×10 mL), and brine (2×10 mL), and then dried (Na2SO4). After the solvent was removed, the residue was dissolved in dry DMF (5 mL) and lithium iodide (7 mg, 48 μmol) and sodium azide (78 mg, 1.2 mmol) were added. The reaction mixture was stirred at 80° C. for 18 h and then was cooled to room temperature. Water (15 mL) was added, and the suspension was extracted with CH2Cl2 (3×20 mL). The combined organic layer was washed with water (3×30 mL) and brine (2×20 mL), dried (Na2SO4), and concentrated under vacuum. The residue was purified by chromatography (hexanes/EtOAc 4:1) to give 20 (119 mg, 67%). 1H NMR δ 7.14-7.04 (m, 4H), 5.02 (s, 1H), 3.89 (d, 2H, J=11.6 Hz), 3.67 (d, 2H, J=11.6 Hz), 3.24 (t, 2H, J=7.2 Hz), 2.60-2.50 (m, 4H), 1.97 (t, 2H, J=8.0 Hz), 1.66-1.56 (m, 4H), 1.47 (s, 9H), 1.43 (s, 3H), 1.41 (s, 3H), 1.40-1.36 (m, 2H); 13C NMR δ 154.7, 139.7, 139.2, 128.3, 128.2, 98.2, 79.1, 66.2, 51.6, 51.2, 35.2, 33.5, 30.9, 28.6, 28.5, 28.3, 27.3, 26.2, 19.6. HRMS m/z: calcd for C24H38N4NaO4 (MNa+), 469.2785; found, 469.2786.

المصدر