تفاعل #2146694

معادلة التفاعل

2-[4′-(3″-fluoropropoxy)phenyl]-6-methoxymethoxyimidazo[1,2-a]pyridine

hydrochloric acid

water

→

2-[4′-(3″-fluoropropoxy)phenyl]-6-hydroxyimidazo[1,2-a]pyridine

المردود 47.1%

المذيبات

isopropyl alcohol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThen, the mixture was refluxed for 23 hours
2. 2
   درجة الحرارةAfter the reaction solution was cooled
3. 3
   استخلاصextracted twice by a salting-out extraction procedure
4. 4
   workup.ADDITIONwith addition of sodium chloride
5. 5
   تجفيفThe combined chloroform layer was dried over anhydrous magnesium sulfate
6. 6
   أخرىThe resulting crude product was purified by silica gel column chromatography (elution solvent: chloroform/methanol=10/1)

الإجراء التجريبي

1.18 g (corresponding to 3.57 mmol) of 2-[4′-(3″-fluoropropoxy)phenyl]-6-methoxymethoxyimidazo[1,2-a]pyridine was dissolved in 29 mL of isopropyl alcohol, and 0.59 mL of conc. hydrochloric acid was added thereto. Then, the mixture was refluxed for 23 hours. After the reaction solution was cooled, the solution was poured into water, and extracted twice by a salting-out extraction procedure using chloroform with addition of sodium chloride. The combined chloroform layer was dried over anhydrous magnesium sulfate. The resulting crude product was purified by silica gel column chromatography (elution solvent: chloroform/methanol=10/1), to obtain 481 mg (corresponding to 1.68 mmol) of 2-[4′-(3″-fluoropropoxy)phenyl]-6-hydroxyimidazo[1,2-a]pyridine (hereinafter referred to as Compound 2) (FIG. 3, Step 10).

المصدر