تفاعل #2145377

معادلة التفاعل

2,4-dichlorophenol

1-bromo-3-methoxy-3-methyl-2-butanone

potassium carbonate

→

1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone

المردود 85.7%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux temperature for 30 minutes
3. 3
   درجة الحرارةThe reaction mixture was cooled
4. 4
   ترشيحfiltered
5. 5
   أخرىthe solvent evaporated from the filtrate
6. 6
   أخرىseparated as a white crystalline solid

الإجراء التجريبي

A stirred mixture of 13.04 g (0.08 mole) of 2,4-dichlorophenol, 15.61 g (0.08 mole) 1-bromo-3-methoxy-3-methyl-2-butanone, and 11.1 g (0.08 mole) powdered potassium carbonate in 300 ml acetonitrile was heated at reflux temperature for 30 minutes. The reaction mixture was cooled, filtered, and the solvent evaporated from the filtrate. The residual oil was taken up in hexane and cooled to -20° C., whereupon the product separated as a white crystalline solid. There was thus obtained 19 g (85.7% yield) of 1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone, m.p. 45.5°-47.5° C.

المصدر