تفاعل #214462

معادلة التفاعل

4-amino-2-chloro-6,7,8-trimethoxy-quinazoline

2-(4-piperidinyl)-isoindolin-1-one

sodium carbonate

→

2-[1-(4-amino-6,7,8-trimethoxy-2-quinazolinyl)-4-piperidinyl]-isoindolin-1-one monohydrochloride

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحIt is filtered
2. 2
   أخرىthe filtrate evaporated
3. 3
   workup.DISSOLUTIONthe residue dissolved in methylene chloride
4. 4
   غسيلthe solution washed with aqueous sodium bicarbonate
5. 5
   أخرىThe organic layer is separated
6. 6
   أخرىdried
7. 7
   أخرىevaporated
8. 8
   درجة الحرارةin refluxing isopropanol
9. 9
   أخرىThe precipitate formed
10. 10
    ترشيحis filtered off
11. 11
    أخرىtriturated with warm ethanol

الإجراء التجريبي

The mixture of 5.39 g of 4-amino-2-chloro-6,7,8-trimethoxy-quinazoline, 4.32 g of 2-(4-piperidinyl)-isoindolin-1-one, 4.24 g of anhydrous sodium carbonate and 75 ml of dimethylformamide is stirred under nitrogen at 125°-130° for 16 hours. It is filtered, the filtrate evaporated, the residue dissolved in methylene chloride and the solution washed with aqueous sodium bicarbonate. The organic layer is separated, dried, and evaporated. The residue is suspended in refluxing isopropanol and acidified with hydrogen chloride to pH=1. The precipitate formed is filtered off and triturated with warm ethanol to yield the 2-[1-(4-amino-6,7,8-trimethoxy-2-quinazolinyl)-4-piperidinyl]-isoindolin-1-one monohydrochloride melting at 234° (dec.).

المصدر